Updated: Oct 9
We have been getting so many questions about why there is a difference between the two monitors, that we have got one our experts Aaron day from fatforweightloss.com.au to help us to explain the science behind this.
So, this post and device will hopefully address some of those issues, plus get into some of the science as to why breath ketones might be a new measurement point.
WHAT ARE KETONES?
Let me give you some simple science behind ketones because there seems to be a lot of people trying to match this device to a blood ketone meter, which is the wrong way to go about it. Let me explain.
In the human body, there are three types of ketones.
Acetoacetate, which is created by the breakdown of fatty acids in your bodyBeta-hydroxybutyrate – or commonly known as BHB, is the ketone body widely found in your blood which is broken down from acetoacetate.Acetone – Which is a waste product produced by the breakdown of acetoacetate into BHB.
Acetoacetate is like the mother of all ketones. Its created in the body through the breakdown of fatty acids through ketogenesis, where 3 acetyl CoA molecules bond to eventually form Beta-hydroxybutyrate through an enzyme known as beta-hydroxybutyrate dehydrogenase.
This can also occur non-enzymatically to form acetone, which is then excreted in the breath.
Now, that might sound complicated, and to be honest, it is. The main thing I want you to take away is that when your body is using acetoacetate (the mother ketone), you are either generating BHB or Acetone.
So, there are 3 ketones. You might be wondering… but I thought there was only 1?
HOW DO I TELL IF I’M IN KETOSIS OR NOT… HOW DO I KNOW IF I’M GOING TO BE LOSING WEIGHT?
I’ll get to that shortly, but first, let us go over the 3 ketones, and highlight which testing mechanism is testing which ketone body.
As you know, there are 3 types of ketone testing methods.
There are urine strips, which test for excess acetoacetate in your urineThere are blood testing devices, which test for beta-hydroxybutyrate in your bloodThere are breath meters, which measure acetone in your breath.
And remember, acetone is produced through the breakdown of acetoacetate. It is a ketone, but it’s not actually used in the body.
HOW DO URINE STRIPS AND BREATH METERS STACK UP TO TESTING YOUR BLOOD?
Well, the issue is that they are all testing different ketone bodies, so they will never match up completely. You shouldn’t be trying to compare them directly.
Okay, so which one should I be testing? Well, this is also affected by what stage of keto you are in.
In the first few weeks, sometimes even months when starting a ketogenic diet, your body will produce a surge of ketones that eventually diminish over time.
Why do they diminish? Well, your body eventually figures out how many ketones you need, and only creates as much as it needs.
If you want to know more about this, there is a fantastic interview that Mike Mutzel from High-Intensity Health recorded with Joe Anderson (PHD) that goes into much more detail about this process.
ARE KETONE URINE STRIPS USEFUL?
So for the countless videos out there explaining that pee sticks are not helpful, the reason why they don’t work after a certain amount of time is that your body stops removing acetoacetate (the mother ketone), and starts breaking it down into BHB and acetone.
ARE BLOOD KETONE METERS ACCURATE?
Okay, so a blood meter must always show if you’re in ketosis or not, right?
Well, as many users have found, maintaining a level of nutritional ketosis might get harder and harder if you’re trying to measure blood ketones for the exact same reason.
A blood ketone meter is measuring how many free beta hydroxybutyrate ketones are present in your blood. It doesn’t indicate how much you’re actually using.
If your body has become more efficient at burning fat for fuel, then you’ll likely see reduced numbers on a blood ketone meter as well.
In saying that, BHB is a much more accurate test than acetoacetate because acetoacetate is an unstable molecule, which is why it can currently only be measured in your blood in a lab.
ARE BREATH KETONE METERS ACCURATE?
So, that brings me to the last method. Breath ketones, or known as acetone. Now, if acetoacetate is being broken down into BHB and acetone, and your body uses both acetoacetate and BHB, then trying to measure those numbers can be troublesome because you’re actually using them.
Blood ketones are much more accurate due to their limited volatility, but what about measuring acetone, which is not being used, only being discarded?
Initially, I thought that acetone in your breath would eventually go away. But maybe over time, the microbiome in your mouth changes due to the lack of carbohydrates. The “keto breath” smell might go away, but potentially not because there is less acetone in your breath.
BLOOD KETONES VS BREATH KETONES VS BLOOD GLUCOSE
I did some testing over a few scenarios. Firstly, I wanted to kick myself out of ketosis to find out how quickly I would get back into ketosis, and secondly, I wanted to compare the values between the breath ketone meter and the blood ketone meter in certain situations.
blood ketones vs breath ketones vs blood glucose
blood ketones vs breath ketones
After eating probably 200g+ of carbohydrates on Sunday with my last meal at 7pm, I tested first thing on Monday morning at 7am.Blood ketones were 0.1mmol,breath ketones were 0.00mmol,and blood glucose was 4.6 (82mg/dl). Definitely kicked out of ketosis.So, I fasted until 5pm that day, which put that at a total of 21 hours fasted, and sure enough, I was back into ketosis.My blood ketones were 0.6mmol,breath ketones were 1.4mmol,and my blood glucose was 4.2mmol (76mg/dl).1 hour later, I did a workout (while still fasted), and measured post-workout.Ketones measured 0.1mmol,breath ketones were 1.2mmol,and blood glucose was 5.4mmol (98mg/dl). (The workout included some high-intensity intervals, which is the reason why my glucose was up, and my blood ketones were down, but interestingly my breath ketones stayed in the same range.)The next day at 7am, I tested.Blood ketones, 0.4mmol,1.2mmol breath ketones,and blood glucose was 4.7mmol (84mg/dl). No breakfast.3 hours later, I attempted to spike those ketones using MCT oil. I took 2 tbsp MCT oil and measured 1 hour later.Blood ketones were 0.5mmol,breath ketones were 1.0mmol,and blood glucose was 4.9mmol.Another 2 hours later, I tried to spike my ketones using exogenous ketones (BHB). I recorded 30 minutes after taking the BHB at1.0mmol blood ketones,1.2mmol breath ketonesand 4.3mmol (78mg/dl).
So in my short 2 days, n=1 experiment, I noticed the following:
I can fast for 21 hours and be back in ketosis.Exogenous BHB has a small effect on blood BHB levelsAfter exercise, BHB levels and blood glucose become elevated, but breath ketones stayed the same.Once in ketosis, breath ketones stayed relatively consistent.
So, from my short testing, it seems as though using a breath ketone meter for me shows the most consistent readings. I’m either in ketosis, or I’m not. I also love that I don’t have to prick my finger every time I want to take a reading.
WHICH WAY SHOULD I MEASURE MY KETONES?
So it’s worth mentioning here that if you are looking to test to see if you’re in ketosis, but it’s your first time, then any of the 3 measurements will work.
Keep in mind that because I’m fat-adapted, my time into ketosis was much faster.
However, if you’ve been keto for a while now, it might be worth getting either a blood ketone meter or a breath ketone meter.
The only downside to the blood ketone meters is most chemists only stock small amounts of blood ketone strips.
I’ve had some pretty nasty feedback from the diabetic community because “keto dieters” have been purchasing all the strips, and there is often none left for those who need to test in emergencies for ketoacidosis, which can be a very serious situation.